Fig. 5. Effect of VX-809 on the mutants A1038V and G1961E. The HEK-293 cell line stably expressing (A) A1038V, or (B) G1961E was treated with VX-809 for 16 h. Data are normalized to the 0 µM control. *P<0.05. n=3-4. The protein expression of ABCA4 mutants A1038V, G1961E is significantly increased after treatment with VX809.